Massimiliano Sassoli de Bianchi earned a degree in physics from the University of Lausanne (UNIL), Switzerland, in 1989. From 1990 to 1991, he served as an assistant at the Department of Theoretical Physics (DPT) of the University of Geneva (UNIGE), where he studied the foundations of quantum theory with Constantin Piron. In 1992, he joined the Institute of Theoretical Physics (IPT) at the Swiss Federal Institute of Technology in Lausanne (EPFL), and following a fruitful scientific collaboration with Ph. A. Martin, he obtained his PhD in 1995 with a study on time observables in quantum scattering theory.

Since 1996, he has worked as a manager in the private sector, as an independent researcher, and as a teacher. In 2010, he founded the Laboratory of Basic Self-Research (LAB), whose mission is the development and dissemination of skills and knowledge aimed at maximizing human potential. Also in 2010, he initiated a scientific correspondence with Diederik Aerts, through which he reconnected with the ideas of the Geneva–Brussels school, leading over the years to a productive scientific collaboration.

In 2016, he joined the Center Leo Apostel for Interdisciplinary Studies (CLEA) at the Vrije Universiteit Brussel (VUB), collaborating and interacting with many of its members. His research focuses on the foundations of physical theories, quantum mechanics, and quantum cognition. He is also active in the exploration of consciousness, primarily from an experiential, first-person perspective (inner research). He is the editor of the journal AutoRicerca and president of the company Area 302, whose mission is the promotion and organization of courses, seminars, conferences, congresses, and other activities of scientific, educational, cultural, artistic, and social value.